Is this the most important cardiology study of the last decade?

In recent years, progress in the field of cardiology has been painfully incremental. We have enjoyed small gains–a better ablation catheter and mapping system, a couple of new anti-platelet drugs, maybe better stents, and even the highly touted anticoagulant drugs are within 99% in efficacy and safety of warfarin. Major breakthroughs, though, are non-existent. (And please don’t tell me squishing valves in the frail elderly is a major advance.)

This absence of game-changing type progress has an explanation. Perhaps the answer will be obvious after I tell you about the most important cardiology medical study of the last decade.

Its title includes atrial fibrillation but it is much more than a rhythm study.

Screen Shot 2014-08-27 at 6.03.14 AMEffect of Weight Reduction and Cardiometabolic Risk Factor Management on Symptom Burden and Severity in Patients With Atrial Fibrillation–A Randomized Clinical Trial

This is a trial of a novel treatment strategy for atrial fibrillation. Patients enrolled in the study were overweight Australians referred to an urban arrhythmia center in Adelaide for symptomatic AF. The researchers compared an intensive (physician-led) intervention approach to weight reduction and risk factor (high blood pressure, sleep apnea, alcohol intake, diabetes) management to the standard of care.

The study was born from two facts: One was that there is a long waiting list to get AF ablation in Australia. There was time. The second was that this group of researchers previously discovered (in a sheep model of obesity) that weight reduction had beneficial rhythm and structural effects on the heart. If it worked in sheep, it would likely work in humans, went the thinking.

Patients in the intervention group were referred to a specialized clinic (not an arrhythmia clinic) where a team worked with patients on basic health measures. This meant strict attention to calorie reduction for weight loss, including meal replacement if necessary. It also meant attention to blood pressure, sleep apnea, blood sugar control, lipid lowering and alcohol and smoking cessation. The control group also got excellent care; risk factors were treated and patients were given good advice on losing weight.

I know what you may be thinking: This does not sound like electrophysiology; it sounds like general internal medicine. And it is–and that is the point.

What makes this trial so important are the results–and the implications of the results.

The trial is free on the JAMA website, so you can read it yourself. There is also a 6-minute podcast with senior author, Professor Prash Sanders. Here are the study’s major findings:

  1. BMI and waist circumference decreased in both groups, but the intervention group lost much more. (Patients in the intervention group lost–on average–6 inches in waist circumference.)
  2. AF symptom burden and severity in the intervention group dropped significantly after 3 months and the curves continued to separate over time. (The graphs are impressive. See Fig 2.)
  3. 7-day ECG recordings from the intervention group, taken at baseline and 12-months, revealed significantly fewer AF episodes (3.3 to 0.62) and shorter duration of episodes (1176 min to 491 min). No significant changes were seen in the control group.
  4. On echo, left atrial size and volume, posterior wall thickness, and myocardial mass all decreased significantly in the intervention group. (This is a huge point because it provides a mechanism for improvement.)
  5. Cardiometabolic risk factors improved in both groups, but there was a significant decrease in numbers of patients with high blood pressure, elevated lipids, and alcohol consumption greater than 30g/wk in the intervention group.
  6. Pill burden decreased in the intervention group and increased in the control group.
  7. Catheter ablation was performed in 14/75 patients in the control group compared with 10/75 in the intervention group.

Yes, it’s a small study from one center in Australia. But look at those findings; look past the AF reduction. Think big picture. Consider what these results say about the practice of medicine. It is so clear to me.

For my entire career, the default has been to treat risk factors and late manifestations of disease. We prescribe medication for high blood pressure and diabetes. We ablate the left atrium to treat sources of atrial fibrillation–the irony being that scar leads to AF and burns/freezes create scar. The reason we do all this treating is because we fail to see these diseases as unnecessary. We don’t think it is possible, or worse, we don’t trust people to make good choices. And this failing is mostly on us physicians.

These researchers have shown both doctors and patients that it is possible not to have lifestyle diseases. They have given us proof that, if you try hard enough, structural heart disease and blood vessel disease and insulin resistance may be reversed. The key word: motivation.

Here is where the skeptics come in. They point out that these sort of results are not possible in the real world. They say: in developed societies where food is abundant and technology makes life easy, weight loss is hard. Really hard.

Okay, I get that. But why is it so?

One reason it’s so hard is because the medical establishment collectively gives in. Look at this Tweet from Dr Rajeev Pathak, one of the Australian researchers.

Respect, teach, and convince patients. These are our major roles as professional caregivers. To doctor is to teach. We aren’t just technicians and medication prescribers.

Of course there will always be a need for treating disease. We will need skilled ablation docs as there will still be AF. We will need interventional cardiologists because there will still be heart attacks. And so on for all medical fields. But we have to stop ignoring the obvious.

Respect. Teach. Convince. What makes this study so damn important is it that should change an entire way of thinking about treating people.

And now you can see why progress in cardiology has been so incremental. It’s because there are no more antidotes to living so large.


Vacation time

Hey all, I am heading out on holiday for a week. I will be without Internet or cellular service, which is something I am looking forward to. I have books to read, and I bought a notebook--the kind with paper. I thought I might try writing words … [Continue reading]